I have Networking > Server address settings > LAN networks blank/default. That sounds like a feature that allows you to specify things as local (maybe that allows for higher bit rate streaming while away or something). I haven’t looked into this at all. For me when I’m away from home lower bandwidth is probably better.

When I turn Tailscale on my iPhone disconnects from AdGuard DNS/VPN. Could I avoid this by using a profile like you described?

Not quite sure I followed all that. I’ve disabled a specific white list for now. When I have access to another computer I will confirm I can’t connect unless I am running Tailscale with the appropriate IP addresses.

I should have bought it when the lifetime was like $40. I used to use it. Had some difficulties with the UI so moved on. Was hoping it would go away instead of being the best choice at 3 times the price. 😖